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Compound: Thymosin Alpha-1 (Thymalfasin)
Amount: 5mg per vial
Format: Lyophilized Powder
Chemical Classification: N-Acetylated 28-Amino-Acid Peptide
Research Category: Thymic Peptide and Immune-Cell Signaling Research
Chemical Profile: Thymosin Alpha-1, also known as thymalfasin or Tα1, is a 28-amino-acid N-terminally acetylated peptide originally identified through research on thymosin fractions. It is studied in immunology, including investigations of dendritic-cell signaling, T-cell-associated pathways and Toll-like receptor-linked responses. It is distinct from thymosin beta-4 and TB-500.
Research Use Only. Not for human or veterinary use.
Thymosin Alpha-1 is a 28-amino-acid peptide originally isolated during studies of thymosin fraction 5, a preparation obtained from thymus tissue. It is also known by the name thymalfasin.
The N-terminus of thymosin alpha-1 is acetylated, which is part of its defined molecular identity. Unlike a peptide mixture or broad thymosin extract, thymosin alpha-1 refers to one particular sequence.
| Specification | Details |
|---|---|
| Compound | Thymosin Alpha-1 |
| Synonyms | Thymalfasin, Tα1 |
| Classification | N-Acetylated Research Peptide |
| Length | 28 Amino Acids |
| Amino-Acid Sequence | SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| N-Terminal Modification | Acetylation |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | Approximately 3,108.3 g/mol |
| CAS Number | 62304-98-7 |
| Form | Lyophilized Powder |
| Amount | 5mg per Vial |
| Research Area | Immune-Cell and Thymic Peptide Research |
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
The sequence contains 28 amino-acid residues, with an acetyl group at its N-terminus. Researchers distinguish the peptide from other thymosin-family members on the basis of sequence and chemical structure.
Thymosin Alpha-1 and thymosin beta-4 share the historical thymosin name but are different compounds.
The two molecules should not be treated as interchangeable.
Thymosin Alpha-1 was identified through work on thymosin fractions and has become a reference compound in the study of thymic peptides.
This research area concerns the molecular signals associated with immune-cell development and regulation. Studies of a defined 28-amino-acid peptide can be distinguished from research involving complex thymus-derived extracts containing many different components.
Published research on thymosin alpha-1 includes investigations of dendritic cells, a type of immune cell that participates in antigen presentation and coordination of immune responses.
Scientists have studied cellular responses to thymosin alpha-1 in experimental models involving immune-cell signaling. These experiments focus on laboratory endpoints, such as the activation state and signaling behavior of particular cell populations.
Toll-like receptors (TLRs) are components of innate immune recognition. A 2004 study in Blood investigated thymosin alpha-1 and dendritic-cell responses through Toll-like receptor-related signaling.
This research helped establish a molecular context for the peptide within immune-cell signaling studies. The findings refer to the conditions and model systems used in the published experiments.
Thymosin alpha-1 is frequently discussed in research relating to T-cell biology, including differentiation, maturation-associated processes and interactions between innate and adaptive immune pathways.
Researchers use cell-specific measurements to examine these processes. Such findings help characterize potential signaling relationships but do not establish that a commercial research vial has a demonstrated clinical effect.
The N-terminal acetyl group and 28-residue sequence are defining structural features. Peptide chemistry research investigates how sequence length, amino-acid placement and terminal modifications influence compound characteristics.
Because thymosin alpha-1 is a single defined peptide, it can be studied separately from larger thymosin mixtures that contain other peptide constituents.
The thymosin alpha-1 literature spans biochemical, cell-culture and animal research involving different preparations. Results from one experimental setting cannot automatically be transferred to another.
Certificates of Analysis (COAs) are posted on the product page when available. To request documentation for a specific lot, contact the Genoscience team with the lot number.
Keep unopened lyophilized vials at −20 °C, protected from light and moisture. Allow the sealed vial to reach room temperature before opening to reduce condensation.
Use suitable laboratory protective equipment and the applicable research-facility handling procedures.
Research Use Only: This product is intended strictly for laboratory research and development.
Not for Human or Veterinary Use: Not intended for consumption, administration or veterinary applications.
Not an Approved Medicine: This material is not marketed as an FDA-approved drug or treatment.
Research Limitations: Published immune-cell findings do not establish clinical safety or efficacy for the supplied research product.
Thymosin Alpha-1 is a defined, N-terminally acetylated 28-amino-acid peptide studied in thymic peptide research and immune-cell signaling.
Yes. Thymalfasin is a name used for the synthetic form of thymosin alpha-1.
They are different research compounds. Thymosin Alpha-1 is a 28-residue peptide associated with immunology studies, while TB-500 is used in discussions of thymosin beta-4-related actin and cytoskeleton research.
The 28-residue sequence is SDAAVDTSSEITTKDLKEKKEVVEEAEN, with an N-terminal acetyl modification.
Thymosin Alpha-1 5mg is listed as lyophilized research material containing 5mg per vial.
When available, the COA for Thymosin Alpha-1 5mg can be found on the product page. You may also contact Genoscience to request a COA or ask about documentation availability for a specific lot.
No. This product is intended strictly for laboratory research and is not intended for human or veterinary use.
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Products are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration.
