TB-500 16 mg Monthly subscription

Original price was: $170.00.Current price is: $110.00. / month

Compound: TB-500 (Thymosin Beta-4 Acetate)

Concentration: 2mg per vial

Format: Lyophilized White Powder (Strictly for In-Vitro Laboratory Use)

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Ket-Glu-Thr-Ile-Glu-Qln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Chemical Classification: Actin-Sequestrating Peptide / Regenerative Protein

Chemical Profile: TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4), a ubiquitous protein found in high concentrations in platelets and wound fluid. The primary biochemical mechanism of TB-500 is its ability to regulate actin polymerization. By sequestering G-actin (globular actin), it maintains a reservoir of actin monomers necessary for the rapid assembly of F-actin filaments. This process is the fundamental driver of cell motility (migration) and cytoskeletal structure, making this peptide a critical reagent for studying tissue remodeling at the cellular level.

Cell Migration & Cytoskeletal Dynamics The core function of TB-500 in research models is the upregulation of actin. Laboratory assays utilize this peptide to observe keratinocyte and endothelial cell migration. Researchers measure how the presence of TB-500 influences the speed and directionality of cell movement across extracellular matrices, a key component of the wound closure process.
Cardiac Tissue Remodeling TB-500 is a primary subject of investigation in cardiovascular research. Preclinical models of ischemia-reperfusion injury utilize the peptide to study the survival of cardiomyocytes and the promotion of angiogenesis (new blood vessel formation). Research focuses on the peptide’s potential to recruit epicardial progenitor cells to sites of damage, providing a model for studying heart tissue preservation and repair signaling.
Ophthalmic & Corneal Research Due to the high concentration of Thymosin Beta-4 naturally present in the eye, TB-500 is frequently used in corneal research. Studies investigate its role in reducing apoptosis (cell death) in corneal epithelial cells and modulating the inflammatory response following alkali injury. It serves as a benchmark for researching non-steroidal pathways for ocular surface protection.
Anti-Inflammatory Modulation Research indicates that TB-500 possesses potent immunomodulatory properties. In models of chronic inflammation, the peptide is observed to downregulate the expression of pro-inflammatory cytokines. This mechanism is explored to understand how metabolic signaling can reduce pathological inflammation and fibrosis in injured tissues without the use of corticosteroids.
Myogenic (Muscle) Differentiation In skeletal muscle studies, TB-500 is utilized to examine the activation of satellite cells (muscle stem cells). Research focuses on the peptide’s ability to accelerate the differentiation of these cells into myotubes, providing data on muscle regeneration kinetics and the maintenance of muscle tone in dystrophic models.

Important Notices:

Research Use Only: This product is sold strictly for scientific research and development purposes.
Handling: The product is provided as a lyophilized powder. Reconstitution requires bacteriostatic water and sterile laboratory equipment (syringes, needles, alcohol pads), which are not included.
Visuals: Vial appearance and cap color may vary from product photos; the label quantity refers to the total active content inside the vial.

Disclaimer: This product is sold explicitly as a chemical reagent for laboratory research and testing purposes only. It is not intended for human consumption, diagnostic, or therapeutic use. Bodily introduction of any kind into humans or animals is strictly forbidden by law.