Price range: $40.00 through $45.00
Compound: MOTS-c (Mitochondrial-Derived Peptide)
Amount: 5mg or 10mg per vial, depending on the selected option
Format: Lyophilized Powder
Chemical Classification: Mitochondrial-Derived Synthetic Research Peptide
Amino-Acid Length: 16 Residues
Chemical Profile: MOTS-c is a 16-amino-acid peptide associated with a short open reading frame within the mitochondrial 12S rRNA gene. It is studied in mitochondrial-to-nuclear signaling, cellular stress responses and AMPK-associated molecular pathways. Its sequence, MRWQEMGYIFYPRKLR, distinguishes it from peptide hormones encoded by nuclear DNA.
Research Use Only. Not for human or veterinary use.
Monthly subscription four vials of 5 mg for total of 20 mg was $400 now $220
MOTS-c is short for mitochondrial open reading frame of the 12S rRNA-c. It is a member of the mitochondrial-derived peptide (MDP) group, which includes short peptides encoded by small open reading frames of mitochondrial DNA.
The original MOTS-c paper, published in 2015, identified a 16-amino-acid peptide encoded in a short open reading frame within the mitochondrial 12S ribosomal RNA region. This location is a notable feature of the compound’s biological origin.
| Specification | Details |
|---|---|
| Compound | MOTS-c |
| Classification | Mitochondrial-Derived Research Peptide |
| Amino-Acid Length | 16 Residues |
| Amino-Acid Sequence | MRWQEMGYIFYPRKLR |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | Approximately 2,174.6 g/mol |
| CAS Number | 1627580-64-6 |
| Listed Amounts | 5mg and 10mg per Vial |
| Form | Lyophilized Powder |
| Research Category | Mitonuclear Signaling and Cellular Stress Research |
MRWQEMGYIFYPRKLR
The 16-residue sequence includes methionine, tryptophan, tyrosine and other standard amino-acid residues. Its short length is one reason it can be studied as a discrete peptide sequence rather than as a full-length protein.
MOTS-c is frequently discussed alongside humanin and the small humanin-like peptides (SHLPs). These peptides share a mitochondrial genetic context but have different sequences and research literature.
MOTS-c is therefore a specific compound rather than a broad synonym for every mitochondrial peptide.
MOTS-c is studied as an example of a peptide encoded within mitochondrial DNA. This research area considers mitochondria not only as cellular energy-associated organelles but also as a source of signaling molecules.
Experiments involving MOTS-c investigate how a defined mitochondrial-derived peptide may affect cellular processes outside the organelle in which its genetic sequence originates.
The original 2015 research on MOTS-c examined biochemical pathways involving the folate cycle and de novo purine biosynthesis. In controlled experimental models, investigators reported relationships between these pathways and downstream signaling.
The study provides background for MOTS-c’s place in cellular metabolism research. Its findings reflect the specified cell and animal models and do not establish clinical effects of a Genoscience research preparation.
AMP-activated protein kinase (AMPK) is an important cellular sensor associated with energy balance and metabolic stress responses.
Early MOTS-c research linked the peptide to AMPK-associated signaling in experimental systems. Studying this relationship allows researchers to explore links between mitochondrial-encoded factors and nuclear-encoded metabolic pathways.
AMPK activity is a measurable biochemical endpoint. Changes in that pathway do not, by themselves, establish a whole-body outcome.
A 2018 Cell Metabolism study investigated the movement of MOTS-c into the nucleus during metabolic stress. Researchers reported nuclear localization and changes in gene expression under selected experimental conditions.
These findings are relevant to the emerging concept of mitonuclear communication: molecular interactions that coordinate mitochondrial and nuclear activities.
The observations describe specified experimental settings rather than a universal behavior of the peptide in every cell type.
Published MOTS-c studies have examined transcriptional responses associated with cellular stress. These include research into antioxidant-response-associated gene programs and interactions with signaling factors.
Gene-expression experiments can help determine which pathways respond under stress conditions. As with other molecular research tools, results depend on the cell line, assay conditions and measured endpoints.
MOTS-c is one example of a growing group of small mitochondrial-encoded factors. It may be compared with other mitochondrial-derived peptides to investigate differences in sequence, cellular localization and reported signaling patterns.
This type of comparative research is important because a shared genetic origin does not imply identical mechanisms or functions for all mitochondrial-derived peptides.
Certificates of Analysis (COAs) are posted on the product page when available. To request documentation for a specific lot, contact the Genoscience team with the lot number.
Store unopened lyophilized material at −20 °C in a dry environment, protected from light and moisture. Allow the sealed vial to reach room temperature before opening to reduce condensation.
Handle with standard laboratory protective equipment and appropriate research-facility procedures.
Research Use Only: This product is intended strictly for scientific laboratory research and development.
Not for Human or Veterinary Use: Not intended for human consumption, administration or veterinary applications.
Not an Approved Medicine: This research product is not marketed as an FDA-approved drug or treatment.
Research Limitations: Laboratory and animal studies of MOTS-c do not establish clinical safety or efficacy for the supplied research material.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame in mitochondrial DNA. It is studied in cell signaling and mitochondrial research.
The name refers to a mitochondrial open reading frame associated with the 12S rRNA region of mitochondrial DNA.
The sequence commonly reported in research is MRWQEMGYIFYPRKLR.
It has its own 16-residue sequence and research literature, distinct from other mitochondrial-derived peptides such as humanin and SHLP-family members.
Genoscience lists MOTS-c in 5mg and 10mg lyophilized vial options.
When available, the COA for MOTS-c 5mg / 10mg can be found on the product page. You may also contact Genoscience to request a COA or ask about documentation availability for a specific lot.
No. Genoscience sells MOTS-c strictly for laboratory research. It is not intended for human or veterinary use.
Original price was: $165.00.$130.00Current price is: $130.00. / month
Original price was: $150.00.$110.00Current price is: $110.00. / month
Original price was: $270.00.$200.00Current price is: $200.00. / month
Original price was: $255.00.$200.00Current price is: $200.00. / month
Original price was: $350.00.$220.00Current price is: $220.00. / month
Original price was: $500.00.$400.00Current price is: $400.00. / month
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Products are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration.
